• Cheng-Gui Zhao, Hong-Bo Xu, and Bin Xu.
• Department of Clinical Laboratory, Zhongda Hospital, Zhongda Hospital, Southeast University, Nanjing, Jiangsu 210009, China.
• Zhonghua Nan Ke Xue. 2019 Aug 1; 25 (8): 696-702.

ObjectiveTo explore the correlation between the rs4705342 gene mutation in the promoter region of the miR-143/ miR-145 cluster and the risk of PCa in the Chinese Han population.MethodsWe enrolled in this study 156 cases of PCa and 188 cancer-free controls. Using TaqMan SNP genotyping assay, we detected the polymorphism of rs4705342 in the promoter region of the miR-143/ miR-145 gene, and performed a stratified analysis on the family history of cancer, body mass index (BMI), age, smoking status, and alcohol consumption of the subjects.ResultsThe proportion of family history of cancer was significantly higher in the case group than in the control (P = 0.01). No statistically significant differences, however, were found between the two groups in age (P = 0.32), BMI (P = 0.79), smoking status (P = 0.47), and alcohol consumption (P = 0.34), nor in the distribution of the TT, CT and CC genotypes (P = 0.07) except in that of the CC and TT/CT combined genotypes (P = 0.01). There were statistically significant differences in the distribution of CC and TT/CT combined genotypes between the non-smoking subgroups, (P = 0.02) and alcohol drinking subgroups (P = 0.03), but not between the clinical stages of PCa (P = 0.81) or the levels of PSA (P = 0.39).ConclusionsThe rs4705342 gene mutation in the promoter region of the miR-143/ miR-145 cluster is significantly associated with the pathogenesis of PCa in the Chinese Han population.

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