• C-Q Su, S-S Lu, M-D Zhou, H Shen, H-B Shi, and X-N Hong.
• Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, 210029, China.
• Clin Radiol. 2019 Feb 1; 74 (2): 154-160.

AimTo examine whether texture analysis (TA) of diffusion-weighted imaging (DWI) combined with conventional magnetic resonance imaging (MRI) could non-invasively predict isocitrate dehydrogenase 1 (IDH1) mutational status in anaplastic gliomas.Materials And MethodsFifty-two patients with histologically confirmed anaplastic glioma was reviewed retrospectively. Conventional MRI was evaluated using the Visually Accessible Rembrandt Images (VASARI) scoring system. TA of DWI based on the entire tumour volume was compared between IDH1-mutant and wild-type tumours by using unpaired Student's t-test. Receiver operating characteristic curve (ROC) and logistic regression were used to assess their diagnostic performance.ResultsSignificant statistical differences in VASARI features and TA of DWI were observed between IDH1-mutant and wild-type tumours (all p<0.05). Using multivariable logistic regression, the proportion of the tumour that was non-enhancing and the entropy of apparent diffusion coefficient (ADC) were found to possess higher prediction potential for IDH1 mutation with areas under the ROC curve (AUC) of 0.918 and 0.724, respectively. A combination of these for the identification of IDH1 mutations improved the AUC to 0.954, with a sensitivity and a specificity of 81% and 96%.ConclusionsThe combined assessment of the conventional MRI and TA of DWI were useful for predicting IDH1 mutation in anaplastic gliomas.Copyright © 2018 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.

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