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J Neurosurg Pediatr · Jul 2017
Case ReportsNovel GOPC(FIG)-ROS1 fusion in a pediatric high-grade glioma survivor.
- Erin N Kiehna, Maxine R Arnush, Benita Tamrazi, Jennifer A Cotter, Debra Hawes, Nathan J Robison, Cindy Y Fong, Dolores B Estrine, Jennifer H Han, and Jaclyn A Biegel.
- Departments of 1 Neurosurgery.
- J Neurosurg Pediatr. 2017 Jul 1; 20 (1): 51-55.
AbstractPediatric high-grade glioma is a rare tumor characterized by high mortality. The authors report the first case of a high-grade glioma associated with a GOPC(FIG)-ROS1 fusion in a pediatric patient. The patient underwent gross-total resection at the age of 4 years, followed by adjuvant high-dose chemotherapy and autologous hematopoietic stem cell rescue. At 30 months after transplantation, she remains disease free.
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