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- Henrik S Thomsen, Peter Marckmann, and Vibeke B Logager.
- Department of Diagnostic Radiology, Copenhagen University Hospital Herlev, Herlev, Denmark. hentho01@heh.regionh.dk
- Magn Reson Imaging Clin N Am. 2008 Nov 1; 16 (4): 551-60, vii.
AbstractGadolinium-based contrast agents were for many years considered safe, but this is no longer the case. The least stable agents may trigger the development of nephrogenic systemic fibrosis (NSF), a generalized fibrotic disorder, in renal failure patients. The use of gadodiamide and gadopentetate dimeglumine is now contraindicated in Europe and Japan in patients who have a glomerular filtration rate less than 30 mL/min/1.73 m(2), including those on dialysis. The fear of NSF, however, should not lead to an enhanced MR imaging examination being denied when there is a good clinical indication to give a gadolinium-based contrast agent.
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