• Hideto Kuribayashi, Philip L Worthington, Daniel P Bradley, David R Checkley, Jean J Tessier, and John C Waterton.
• AstraZeneca, Macclesfield, Cheshire, UK. hideto.kuribayashi@varianinc.com
• J Magn Reson Imaging. 2007 Jun 1; 25 (6): 1248-55.

PurposeTo characterize misregistration artifact in arterial input function (AIF) pixels in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) using a two-dimensional non-echo-planar imaging (EPI)-based gradient-recalled echo (GRE) sequence.Materials And MethodsDynamic gadopentetate-enhanced MRI was acquired in the rat using a semikeyhole acquisition scheme. The AIF was obtained from abdominal aorta pixels. Different sliding-window reconstruction techniques were applied to determine which lines in a series of the semikeyhole acquisition were associated with the misregistration artifacts.ResultsThe misregistration along the phase-encoding direction arose when k-space lines were acquired during the rise-time of the aortic gadolinium concentration. The maximum blood concentration of gadolinium estimated from the phase shift calculation agreed with that estimated from dosage.ConclusionAIF misregistration results from a phase shift due to increasing gadolinium concentration in the aorta, and may need to be considered in small animal DCE-MRI studies with a high rate of rise in the AIF in high-field MR applications.(c) 2007 Wiley-Liss, Inc.

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