• Crit. Rev. Oncol. Hematol. · Jun 2019

    Review Practice Guideline

    Multidisciplinary expert opinion on the treatment consensus for patients with EGFR mutated NSCLC with brain metastases.

    • Santiago Ponce, Jordi Bruna, Oscar Juan, Rafael López, Alejandro Navarro, Ana Laura Ortega, Javier Puente, Eugènia Verger, Adela Bartolomé, and Ernest Nadal.
    • Lung Cancer Clinical Research Unit, Hospital Universitario 12 de Octubre, Av. Cordoba, s/n, 28041 Madrid, Spain. Electronic address: sponceaix@gmail.com.
    • Crit. Rev. Oncol. Hematol. 2019 Jun 1; 138: 190-206.

    AbstractThe presence of an epidermal growth factor receptor (EGFR) mutation is associated with higher incidence of brain metastases in patients with non-small cell lung cancer (NSCLC); however, patients with synchronous brain metastases at diagnosis have generally been excluded from clinical trials. As there is limited clinical evidence for managing this patient population, a multidisciplinary group of Spanish medical and radiation oncologists, and neuro-oncologist with expertise treating brain metastases in lung cancer patients met with the aim of reaching and developing an expert opinion consensus on the management of patients with EGFR mutated NSCLC with brain metastases. This consensus contains 26 recommendations and 20 conclusion statements across 21 questions in 7 areas, as well as a first-line treatment algorithm.Copyright © 2019 Elsevier B.V. All rights reserved.

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