• Cancer treatment reviews · Dec 2015

    Review

    PD-1 and PD-L1 blockade in gastrointestinal malignancies.

    • Hazel Lote, Catherine Cafferkey, and Ian Chau.
    • Department of Medicine, Royal Marsden Hospital, London and Surrey, Sutton SM2 5PT, UK.
    • Cancer Treat. Rev. 2015 Dec 1; 41 (10): 893-903.

    AbstractImmunotherapy represents a major breakthrough in cancer therapy in recent years. Immune-checkpoint blockade using PD-1 and PD-L1 antibodies appears to be one of the most promising immunotherapy approaches. Immunotherapy differs from conventional cancer treatment because of its ability to produce durable responses in some patients. In this review article, we explore the available evidence and summarise current clinical trials for PD-1 and PD-L1 blockade in gastrointestinal malignancies. The challenge now is to develop strategies to increase the efficacy of PD-1 and PD-L1 blockade in gastrointestinal cancer patients, such as combination therapy with chemotherapy, radiotherapy or other immunotherapy, along with validating biomarkers to select patients and personalise treatment. Copyright © 2015 Elsevier Ltd. All rights reserved.

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