• Praxis · Oct 2012

    Review

    [Treatment of metastatic melanoma: are we entering the era of targeted treatment?].

    • R von Moos, R Cathomas, M Mark, and F Hitz.
    • Abteilung Medizinische Onkologie/Hämatologie, Kantonsspital Graubünden.
    • Praxis (Bern 1994). 2012 Oct 31; 101 (22): 1423-9.

    AbstractThe treatment of metastatic melanoma has progressed greatly during the last two years. Nowadays melanomas can be divided into molecular subgroups, this being therapeutically relevant. Around 60% of melanomas show a BRAF mutation and can be treated with selected tyrokinase inhibitors. In addition a CTLA-4-antibody was developed which shuts off the natural immune breaking system resulting in a continuous anti-tumor reaction. Angiogenesis inhibitors have shown there importance in different phase II trials. We hope that this represents only the first step of an individualized treatment for metastatic melanoma.

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