• Leukemia · Dec 2019

    Review

    CD19 chimeric antigen receptor-T cells in B-cell leukemia and lymphoma: current status and perspectives.

    • Mohamad Mohty, Jordan Gautier, Florent Malard, Mahmoud Aljurf, Ali Bazarbachi, Christian Chabannon, Mohamed A Kharfan-Dabaja, Bipin N Savani, He Huang, Saad Kenderian, Arnon Nagler, and Miguel-Angel Perales.
    • Service d'Hématologie Clinique et Thérapie Cellulaire, Hôpital Saint-Antoine, Sorbonne Université, INSERM UMRs 938, Paris, France. mohamad.mohty@inserm.fr.
    • Leukemia. 2019 Dec 1; 33 (12): 2767-2778.

    AbstractThe approval of tisagenlecleucel and axicabtagene ciloleucel represents a breakthrough in the field of immune and cellular therapy for hematologic malignancies. These anti-CD19 chimeric antigen receptor-T cells (CAR) proved to be highly effective in the treatment of relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL) and specific histologic subtypes of B-cell non-Hodgkin lymphomas. This expert review aims to summarize the current available research evidence in this field, with a special focus on the different challenges faced by treating physicians, and we also provide future perspectives.

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