• Gan To Kagaku Ryoho · Mar 2004

    [Gastrointestinal stromal tumor].

    • Toshirou Nishida, Takeshi Ohmori, and Hikaru Matsuda.
    • Dept. of Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita 565-0871, Japan.
    • Gan To Kagaku Ryoho. 2004 Mar 1; 31 (3): 331-6.

    AbstractGastrointestinal stromal tumors (GISTs), the most common submucosal tumor in the gut, express the KIT protein. Gain-of-function mutations in the KIT or PDGF-R alpha gene is involved in oncogenesis and growth of GISTs. Although the first-line therapy of resectable GISTs is surgery, imatinib mesylate, a target-based molecule against KIT and PDGF-R alpha proteins, showed remarkable clinical effects and good tolerability for non-resectable GISTs. Now, imatinib is in the first-line for non-resectable GISTs. Resistance against imatinib, however, is proved after long-standing use of the drug.

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