• Vascular medicine · Jun 2013

    Case Reports

    Fatal anaphylactoid reaction associated with heparin-induced thrombocytopenia.

    • Atul Singla, Mohammad R Amini, Martin A Alpert, and Heather L Gornik.
    • Division of Cardiovascular Medicine, University of Missouri School of Medicine, Columbia, Missouri 65212, USA.
    • Vasc Med. 2013 Jun 1;18(3):136-8.

    AbstractAcute systemic (anaphylaxis and anaphylactoid) reactions have been well described in patients with heparin-induced thrombocytopenia (HIT). Both necrotizing and non-necrotizing skin lesions at heparin injection sites have been reported and may occur in 10-20% of patients with HIT. We report herein a patient treated with subcutaneous enoxaparin sodium who developed non-necrotizing erythematous skin lesions at enoxaparin sodium injection sites. A subsequent intravenous bolus of unfractionated heparin produced a fatal anaphylactoid reaction. This suggests that caution should be exercised in the administration of intravenous heparin to patients with non-necrotizing erythematous skin lesions at prior heparin injection sites.

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