• Edward Chow, Ralph M Meyer, Bingshu E Chen, Yvette M van der Linden, Daniel Roos, William F Hartsell, Peter Hoskin, Jackson S Y Wu, Abdenour Nabid, Caroline J A Tissing-Tan, Bing Oei, Scott Babington, William F Demas, Carolyn F Wilson, Rebecca K S Wong, and Michael Brundage.
• Edward Chow, Sunnybrook Odette Cancer Centre, University of Toronto; Rebecca K.S. Wong, Princess Margaret Hospital, Ontario Cancer Institute, University of Toronto, Toronto; Ralph M. Meyer, Juravinski Hospital and Cancer Centre and McMaster University, Hamilton; Bingshu E. Chen, Carolyn F. Wilson, and Michael Brundage, Cancer Research Institute, Queen's University, Kingston, Ontario; Jackson S.Y. Wu, Tom Baker Cancer Centre, University of Calgary, Calgary, Alberta; Abdenour Nabid, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada; Yvette M. van der Linden, Leiden University Medical Centre, Leiden and Radiotherapy Institute Friesland, Leeuwarden; Caroline J.A. Tissing-Tan, Institute for Radiation Oncology Arnhem, Arnhem; Bing Oei, Dr Bernard Verbeeten Instituut, Tilburg, the Netherlands; Daniel Roos, Royal Adelaide Hospital, University of Adelaide, Adelaide, South Australia, Australia; William F. Hartsell, Central DuPage Hospital Cancer Center, Warrenville, IL; Peter Hoskin, Mount Vernon Hospital Cancer Centre, Middlesex, United Kingdom; Scott Babington, Christchurch Hospital, Christchurch, New Zealand; and William F. Demas, Akron City Hospital, Northeast Ohio Medical University, Akron, OH. edward.chow@sunnybrook.ca.
• J. Clin. Oncol. 2014 Dec 1; 32 (34): 3867-73.

PurposeWe previously demonstrated that 48% of patients with pain at sites of previously irradiated bone metastases benefit from reirradiation. It is unknown whether alleviating pain also improves patient perception of quality of life (QOL).Patients And MethodsWe used the database of a randomized trial comparing radiation treatment dose fractionation schedules to evaluate whether response, determined using the International Consensus Endpoint (ICE) and Brief Pain Inventory pain score (BPI-PS), is associated with patient perception of benefit, as measured using the European Organisation for Resesarch and Treatment of Cancer (EORTC) Quality of Life Questionnaire Core 30 (QLQ-C30) and functional interference scale of the BPI (BPI-FI). Evaluable patients completed baseline and 2-month follow-up assessments.ResultsAmong 850 randomly assigned patients, 528 were evaluable for response using the ICE and 605 using the BPI-PS. Using the ICE, 253 patients experienced a response and 275 did not. Responding patients had superior scores on all items of the BPI-FI (ie, general activity, mood, walking ability, normal work, relations with other people, sleep, and enjoyment of life) and improved QOL, as determined by scores on the EORTC QLQ-C30 scales of physical, role, emotional and social functioning, global QOL, fatigue, pain, and appetite. Similar results were obtained using the BPI-PS; observed improvements were typically of lesser magnitude.ConclusionPatients responding to reirradiation of painful bone metastases experience superior QOL scores and less functional interference associated with pain. Patients should be offered re-treatment for painful bone metastases in the hope of reducing pain severity as well as improving QOL and pain interference.© 2014 by American Society of Clinical Oncology.

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