• Gan To Kagaku Ryoho · Aug 2003

    Review

    [Imatinib].

    • Akio Urabe.
    • Division of Hematology, NTT Kanto Medical Center, 5-9-22 Higashi-gotanda, Shinagawa-ku, Tokyo 141-8625, Japan.
    • Gan To Kagaku Ryoho. 2003 Aug 1; 30 (8): 1191-6.

    AbstractImatinib mesylate is an inhibitor of Bcr/Abl tyrosine kinase, which essentially participates the pathogenesis of chronic myelogenous leukemia (CML). Imatinib is highly effective in the treatment of CML. Because imatinib also inhibits c-kit and platelet-derived growth-factor (PDGF) receptor, it may be efficacious against some tumors which possess c-kit or PDGF receptors.

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