• Contact dermatitis · Jun 1996

    Case Reports

    Delayed-type hypersensitivity to subcutaneous lidocaine with tolerance to articaine: confirmation by in vivo and in vitro tests.

    • A J Bircher, S L Messmer, C Surber, and T Rufli.
    • Department of Dermatology, University Hospital, Basel, Switzerland.
    • Contact Derm. 1996 Jun 1; 34 (6): 387-9.

    AbstractA 43-year-old woman suffered from recurrent localized swellings and an eczematous dermatitis starting 1 day after an injection of lidocaine. Intradermal patch and lymphocyte transformation tests revealed sensitization to lidocaine and cross-reactivity to the other aminoacylamide local anesthetics bupivacaine, mepivacaine and prilocaine, but not to articane. Contact allergy to the ester local anesthetics benzocaine, procaine and tetracaine, the quinoline or aminoacylamide cinchocaine, and the preservatives methylparaben and metabisulfite, was excluded. A subcutaneous challenge with articaine was well tolerated.

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