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Ann. Clin. Lab. Sci. · Jan 2006
Case ReportsExtramedullary hematopoiesis in breast after neoadjuvant chemotherapy for breast carcinoma.
- Jun Wang and Farbod Darvishian.
- Department of Pathology, New York University Medical Center, New York, NY 10016, USA.
- Ann. Clin. Lab. Sci. 2006 Jan 1; 36 (4): 475-8.
AbstractWe report incidental extramedullary hematopoiesis (EMH) in breasts of 2 patients following neoadjuvant chemotherapy for locally advanced breast cancer. Neither of the patients had a history of hematologic disorders. After chemotherapy, one of the patients had a complete pathologic response and the other had residual carcinoma. In both cases, EMH was mostly seen as myelopoiesis in a background of chemotherapy-induced changes. In the patient with residual carcinoma, EMH was observed in the contralateral prophylactic mastectomy specimen. EMH should be considered a diagnostic pitfall in the differential diagnosis of unusual cellular infiltrates in breast after neoadjuvant chemotherapy. To our knowledge, the association of EMH and neoadjuvant chemotherapy has not been previously reported.
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