• Carbohydrate polymers · Oct 2014

    Antitumor metastasis activity of pectic polysaccharide purified from the peels of Korean Citrus Hallabong.

    • Eun Hye Lee, Hye-Ryung Park, Myoung-Sook Shin, Sun Young Cho, Hyuk-Joon Choi, and Kwang-Soon Shin.
    • Department of Food Science and Biotechnology, Kyonggi University, San 94-6, Ieui-dong, Youngtong-gu, Suwon, Gyeonggi-do 443-760, Republic of Korea.
    • Carbohydr Polym. 2014 Oct 13; 111: 72-9.

    AbstractA polysaccharide fraction, HBE-III, was successfully purified in a high yield (40.4%) from its crude polysaccharide (HBE-0) which was prepared from pectinase hydrolysates of the peels of the Korean Citrus Hallabong. In experimental lung metastasis studies of Colon 26-M3.1 carcinoma cells, prophylactic administration of HBE-III significantly inhibited lung metastasis in a dose-dependent manner. In an in vitro cytotoxicity analysis, HBE-III (up to 1000 μg/mL) did not affect the growth of Colon 26-M3.1 cells and normal cells. HBE-III enhanced production of IL-6 and IL-12 by murine peritoneal macrophages. In an assay for natural killer (NK) cell activity, HBE-III (1000 μg/mouse, i.v.) significantly augmented NK cytotoxicity against Yac-1 tumor cells. The depletion of NK cells by injection of mouse anti-asialo GM1 serum abolished the inhibitory effect of HBE-III on lung metastasis of Colon 26-M3.1 cells. These data suggest that HBE-III may inhibit tumor metastasis via activation of macrophages and NK cells.Copyright © 2014 Elsevier Ltd. All rights reserved.

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