• Curr Opin Pharmacol · Feb 2003

    Review

    Cytokines: regulation of the hypothalamo-pituitary-adrenocortical axis.

    • Christopher D John and Julia C Buckingham.
    • Department of Neuroendocrinology, Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Hammersmith Campus, Du Cane Road, London W12 0NN, UK.
    • Curr Opin Pharmacol. 2003 Feb 1;3(1):78-84.

    AbstractMany of the pro-inflammatory cytokines that are released in response to immune/inflammatory insults exert marked stimulatory influences on the hypothalamo-pituitary-adrenocortical axis. Thus, they provoke the release of glucocorticoids that, in turn, temper the ensuing immune/inflammatory response, and thereby complete a homeostatic neuroendocrine loop. The mechanisms by which cytokines cause glucocorticoid release are complex and can be affected by repeated or sustained cytokine exposure, gender and age, or counter-regulatory mechanisms.

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