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Clinical lung cancer · Jul 2018
ReviewThe Road Less Traveled: Should We Omit Prophylactic Cranial Irradiation for Patients With Small Cell Lung Cancer?
- Terence T Sio, Anussara Prayongrat, Yun Zhang, Qin Lin, Ting Xu, Zhongxing Liao, and Jinbo Yue.
- Department of Radiation Oncology, Mayo Clinic Arizona, Phoenix, AZ.
- Clin Lung Cancer. 2018 Jul 1; 19 (4): 289-293.
AbstractNew randomized data from Japan have raised questions regarding the use of prophylactic cranial irradiation for patients with extensive-stage small-cell lung cancer but without detectable brain metastases on magnetic resonance imaging. In the present focused review, we examine the general role of prophylactic cranial irradiation in the management of small-cell lung cancer and present relevant controversies from both sides of the discussion. Future directions for clinical investigation and research are also highlighted. Strategies for neurocognitive protection, including memantine use and hippocampal sparing using modulated radiotherapy techniques, are also presented.Copyright © 2018 Elsevier Inc. All rights reserved.
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