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Clin Colorectal Cancer · Oct 2007
Optimizing administration of epidermal growth factor receptor-targeted agents in the treatment of colorectal cancer.
- Eric Van Cutsem.
- Digestive Oncology Unit, University Hospital Gasthuisberg, Leuven, Belgium. eric.vancutsem@uz.kuleuven.ac.be
- Clin Colorectal Cancer. 2007 Oct 1; 6 Suppl 2: S60-5.
AbstractThe monoclonal antibodies against the epidermal growth factor receptor (EGFR) are active in patients with metastatic colorectal cancer (CRC; mCRC). This activity has been shown initially in irinotecan- and chemotherapy-refractory mCRC. The correlation of rash after EGFR inhibitors and activity has led to the concept of the dose until rash study. Clinical trials evaluating this concept are ongoing. However, many unresolved challenges remain regarding this question. New challenges include the development of the most optimal schedule of the EGFR inhibitors and the evaluation of their role in less advanced stages and in the preoperative treatment of liver metastases of CRC.
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