• Megan P Rothney, Alberico L Catapano, Jin Xia, Wynn K Wacker, Cristina Tidone, Liliana Grigore, Yi Xia, and David L Ergun.
• Computational Biology and Biostatistics Laboratory, GE Global Research Center, Niskayuna, New York, USA.
• Obesity (Silver Spring). 2013 Sep 1; 21 (9): 1798-802.

ObjectiveTo examine the association between cardiometabolic risk factors and visceral adipose tissue (VAT) measurements using a dual-energy X-ray absorptiometry (DXA) based approach.Design And MethodsAn analysis of cross-sectional relationships between DXA VAT measured using CoreScan (GE Healthcare) and cardiometabolic indicators was conducted on a sample of 939 subjects (541 females and 398 males; average age, 56 years; average BMI, 26 kg/m2) who had previously undergone a total body DXA scan as well as measurements of key cardiometabolic risk factors.ResultsSex-specific, age-adjusted multivariable regression analysis showed that for both men and women, DXA VAT was significantly associated with increased odds of hypertension, impaired fasting glucose, metabolic syndrome, and type 2 diabetes (P < 0.001). After additional model adjustment for BMI and waist circumference, the odds ratio (per SD change in VAT) for type 2 diabetes was 2.07 for women and 2.25 for men. Similarly, the odds ratio for metabolic syndrome for women was 3.46 and for men was 1.75.ConclusionsVAT measured using DXA showed a significant association with cardiometabolic risk factors and disease. These relationships persist after statistical adjustment for age, BMI, and waist circumference. DXA VAT may provide a new accessible option for quantifying VAT-related cardiometabolic risk.Copyright © 2012 The Obesity Society.

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