• Blood purification · Jan 2021

    Case Reports

    The Seraph®-100 Microbind Affinity Blood Filter Does Not Affect Vancomycin, Tacrolimus, and Mycophenolic Acid Plasma Concentrations.

    • de GeusHilde R HHRHDepartment of Intensive Care, Erasmus University Medical Centre Rotterdam, Rotterdam, The Netherlands., Tim Smeets, HoekRogier A SRASDepartment of Pulmonary Medicine, Erasmus University Medical Centre Rotterdam, Rotterdam, The Netherlands., Henrik Endeman, and Nicole Hunfeld.
    • Department of Intensive Care, Erasmus University Medical Centre Rotterdam, Rotterdam, The Netherlands.
    • Blood Purif. 2021 Jan 1; 50 (6): 971-975.

    AbstractExtracorporeal blood purification is considered an adjunct therapy in critically ill patients with life-threatening conditions such as sepsis and septic shock. It consists of cytokine removal, removal of endotoxins, a combination of both, or the removal of pathogens themselves. The latter technique was introduced for clinical application very recently. This case study describes a case of a 69-year-old female lung transplant recipient patient with a persistent VV-ECMO-related septic deep vein thrombosis with continuous renal replacement therapy-dependent acute kidney injury initiated on the Seraph®-100 Microbind Affinity Filter in order to control the persistent bacteraemia with coagulase-negative staphylococci. Drug plasma concentrations (vancomycin, tacrolimus, and mycophenolic acid) were measured before and after the device to calculate absorber-related drug clearance.© 2021 The Author(s). Published by S. Karger AG, Basel.

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