• Keiichiro Yoshinaga, Noboru Oriuchi, Hiroshi Wakabayashi, Yuuki Tomiyama, Megumi Jinguji, Tetsuya Higuchi, Daiki Kayano, Makoto Fukuoka, Anri Inaki, Ayane Toratani, Shozo Okamoto, Tohru Shiga, Yoichi M Ito, Masatoyo Nakajo, Masayuki Nakajo, Seigo Kinuya, Drafting Committee for Guidelines on Internal Radiotherapy with ¹³¹I-MIBG, Japanese Society of Nuclear Medicine in Oncology and Imunology, and Japanese Society of Nuclear Medicine.
• Department of Molecular Imaging, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
• Endocr. J. 2014 Jan 1; 61 (12): 1171-80.

AbstractEffective treatments for malignant neuroendocrine tumors are under development. While iodine-131 metaiodobenzylguanidine (¹³¹I-MIBG) radiotherapy has been used in the treatment of malignant neuroendocrine tumors, there are few studies evaluating its therapeutic effects and safety in a multicenter cohort. In the current study, we sought to evaluate the effects and safety of ¹³¹I-MIBG therapy for conditions including malignant pheochromocytoma and paraganglioma within a multicenter cohort. Forty-eight malignant neuroendocrine tumors (37 pheochromocytoma and 11 paraganglioma) from four centers underwent clinical ¹³¹I-MIBG radiotherapy. The tumor responses were observed before and 3 to 6 months after the ¹³¹I-MIBG radiotherapy in accordance with RECIST criteria. We also evaluated the data for any adverse effects. The four centers performed a total of 87 ¹³¹I-MIBG treatments on 48 patients between January 2000 and March 2009. Of the treatments, 65 were evaluable using RECIST criteria. One partial response (PR), 40 stable disease (SD), and 9 progressive disease (PD) in malignant pheochromocytoma were observed after each treatment. Fourteen SD and one PD-were observed in paraganglioma. Patients with normal hypertension (systolic blood pressure (BP) > 130 mmHg) showed significantly reduced systolic BP after the initial follow-up (n=10, 138.1±8.2 to 129.5±13.5 mmHg, P=0.03). In adult neuroendocrine tumors with a treatment-basis analysis, there were side effects following 41 treatments (47.1%) and most of them (90.2%) were minor. In this multicenter registry, PR or SD was achieved in 84.6% of the treatment occasions in adult neuroendocrine tumors through ¹³¹I-MIBG radiotherapy. This indicated that most of the ¹³¹I-MIBG radiotherapy was performed safely without significant side effects.

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