• Trends Genet · Nov 2020

    Host Polymorphisms May Impact SARS-CoV-2 Infectivity.

    • Patrick Brest, Sadal Refae, Baharia Mograbi, Paul Hofman, and Gerard Milano.
    • Université Côte d'Azur, Centre Antoine Lacassagne, CNRS, Inserm, IRCAN, FHU-OncoAge, Nice, F-06189, France.
    • Trends Genet. 2020 Nov 1; 36 (11): 813-815.

    AbstractBased on a broad public database compilation, we support the hypothesis that germinal polymorphisms may regulate the expression of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cellular target itself and proteases controlling the process of its shedding or, conversely, its internalization. Consequently, a genetic influence on individual susceptibility to coronavirus disease 2019 (COVID-19) infection is strongly suspected.Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.

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