• Eur. Respir. J. · Jun 1997

    Case Reports

    Propylthiouracil-induced alveolar haemorrhage associated with antineutrophil cytoplasmic antibody.

    • M Ohtsuka, Y Yamashita, M Doi, and S Hasegawa.
    • Dept of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba-shi, Ibaraki, Japan.
    • Eur. Respir. J. 1997 Jun 1; 10 (6): 1405-7.

    AbstractPropylthiouracil (PTU) is known to cause vasculitis as a rare complication. We report the case of a patient who developed alveolar haemorrhage and haematuria whilst treated with PTU. The serum was positive for antineutrophil cytoplasmic antibody (ANCA) with myeloperoxidase (MPO) specificity (MPO-ANCA). All symptoms resolved completely after discontinuation of PTU. Alveolar haemorrhage or pulmonary-renal syndrome associated with antineutrophil cytoplasmic antibody with myeloperoxidase specificity may be a new complication of propylthiouracil therapy.

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