• Ann. Rheum. Dis. · Nov 2014

    Multicenter Study Observational Study

    Association of changes in delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) with changes in cartilage thickness in the medial tibiofemoral compartment of the knee: a 2 year follow-up study using 3.0 T MRI.

    • Michel D Crema, David J Hunter, Deborah Burstein, Frank W Roemer, Ling Li, Felix Eckstein, Nitya Krishnan, Marie-Pierre Hellio Le-Graverand, and Ali Guermazi.
    • Department of Radiology, Quantitative Imaging Center, Boston University School of Medicine, Boston, Massachusetts, USA Boston Imaging Core Lab, Boston, Massachusetts, USA Department of Radiology, Hospital do Coração (HCor) and Teleimagem, São Paulo, Brazil.
    • Ann. Rheum. Dis. 2014 Nov 1; 73 (11): 1935-41.

    ObjectiveTo determine the association between changes in the delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) index over 2 years as a measure of cartilage proteoglycan concentration, with changes in cartilage thickness in the medial tibiofemoral compartment of knees in middle-aged women.MethodsOne hundred and forty-eight women (one knee for each subject) aged ≥40 years were included. 3.0 T MR images of the knee were acquired at baseline, 1 year and 2 years. Three-dimensional (3D) spoiled gradient recalled echo (SPGR) sequences (for cartilage thickness) and 3D inversion recovery-prepared SPGR sequences after dGEMRIC were acquired. Segmentation was performed in the medial central (weight-bearing) femur and tibia to determine cartilage proteoglycan concentration and thickness. The association of change in the dGEMRIC indices between baseline and 1-year follow-up with (a) concomitant changes in cartilage thickness and (b) change in cartilage thickness between 1 and 2 years was assessed using linear regression.ResultsIn the whole-sample model, a decrease in dGEMRIC indices over time at the central medial femur significantly predicted an increase in cartilage thickness at both the central medial femur (p=0.008) and the medial tibia (p=0.04).ConclusionsA decrease in dGEMRIC indices was associated with an increase in cartilage thickness in the medial compartment. Our results suggest that an increase in cartilage thickness may also be related to a decrease in proteoglycan concentration, which may represent swelling of cartilage in early stages of degeneration.Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

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