• Biomarkers · Feb 2012

    The impact of admission procalcitonin on prognosis in acute coronary syndromes: a pilot study.

    • Claudio Picariello, Chiara Lazzeri, Paola Attanà, Marco Chiostri, Gian Franco Gensini, and Serafina Valente.
    • Intensive Cardiac Care Unit, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy. claudx@hotmail.com
    • Biomarkers. 2012 Feb 1; 17 (1): 56-61.

    BackgroundAvailable evidence on the prognostic role of procalcitonin levels in acute coronary syndromes (ACS) is so far controversial.AimsTo evaluate the association between procalcitonin, major cardiovascular events (MACE) and total mortality in acute coronary syndromes.MethodsProcalcitonin levels were measured in 247 patients admitted to our Intensive Cardiac Care Unit (ICCU) with ACS. Three subgroups were considered according to procalcitonin levels.ResultsAt Cox regression analysis, procalcitonin levels were both an unadjusted and an adjusted predictor (corrected for diagnosis and TnI) of intra-ICCU mortality and of 1-year follow-up MACE and total mortality.ConclusionsIn ACS, admission procalcitonin values identify a "higher risk" group of patients for short and long-term mortality.

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