• Surg. Oncol. Clin. N. Am. · Jul 2016

    Review

    Neoadjuvant Therapy in Non-Small Cell Lung Cancer.

    • Yifan Zheng, Michael T Jaklitsch, and Raphael Bueno.
    • Division of Thoracic Surgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
    • Surg. Oncol. Clin. N. Am. 2016 Jul 1; 25 (3): 567-84.

    AbstractLocally advanced (stage IIIA) non-small cell lung cancer (NSCLC) is confined to the chest, but requires more than surgery to maximize cure. Therapy given preoperatively is termed neoadjuvant, whereas postoperative therapy is termed adjuvant. Trimodality therapy (chemotherapy, radiation, and surgery) has become the standard treatment regimen for resectable, locally advanced NSCLC. During the past 2 decades, several prospective, randomized, and nonrandomized studies have explored various regimens for preoperative treatment of NSCLC. The evaluation of potential candidates with NSCLC for neoadjuvant therapy as well as the currently available therapeutic regimens are reviewed.Copyright © 2016 Elsevier Inc. All rights reserved.

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