• Jacques T YaDeau, Vincent R LaSala, Leonardo Paroli, Richard L Kahn, Kethy M Jules-Elysée, David S Levine, Barbara L Wukovits, and Jane Y Lipnitsky.
• Department of Anesthesiology, Hospital for Special Surgery, Weill Medical College of Cornell University, New York City, NY 10011, USA. yadeauj@hss.edu
• Anesth. Analg. 2008 Jun 1;106(6):1916-20.

BackgroundWe tested the hypothesis that 100 microg clonidine added to 0.375% bupivacaine would prolong the duration of analgesia from popliteal fossa nerve blockade.MethodsNinety-nine patients scheduled for hospital admission after foot or ankle surgery entered this randomized, double-blind, placebo-controlled trial. Patients received a popliteal fossa block (nerve stimulator technique, via the posterior approach) using 30 mL 0.375% bupivacaine, with epinephrine. Patients were randomized to receive no clonidine, 100 microg clonidine IM, or 100 microg clonidine with bupivacaine for the popliteal block. Patients also received a combined spinal-epidural anesthetic, a saphenous nerve block, and postoperative IV patient-controlled analgesia. The primary outcome was patient-reported duration of analgesia.ResultsDuration of analgesia was statistically longer in the block clonidine group (18 +/- 6 h for clonidine with bupivacaine vs 14 +/- 7 h for IM clonidine and 15 +/- 7 h for control, P = 0.016 for control vs clonidine with bupivacaine). Pain scores, analgesic use, and side effects attributable to pain management were similar among groups.ConclusionsClonidine significantly prolongs the analgesic duration after popliteal fossa nerve blockade with bupivacaine.

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