• Surg. Oncol. Clin. N. Am. · Apr 2017

    Review

    Current Progress in Human Epidermal Growth Factor Receptor 2 Targeted Therapies in Esophagogastric Cancer.

    • Yelena Y Janjigian and Maria Ignez Braghiroli.
    • Gastrointestinal Oncology Service, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, 300 East 66th Street, Room 1033, New York, NY 10065, USA.
    • Surg. Oncol. Clin. N. Am. 2017 Apr 1; 26 (2): 313-324.

    AbstractEsophagogastric cancer is a worldwide health problem. The addition of the epidermal growth factor receptor 2 (HER2)-directed antibody trastuzumab to chemotherapy increased the overall survival of patients with metastatic HER2-positive esophagogastric cancer. This article discusses the available data to support HER2 as validated biomarker and recently completed and ongoing clinical trials of HER2-directed agents in metastatic and localized disease. Also reviewed is the mechanisms of resistance for HER2-directed therapy and ongoing research strategies including new imaging techniques and studies with patient-derived xenografts.Copyright © 2016 Elsevier Inc. All rights reserved.

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