• Brain research · Mar 1981

    Trimethadione effects on cholinergic responses in Aplysia neurons.

    • W M King and N R Kreisman.
    • Brain Res. 1981 Mar 23; 209 (1): 221-6.

    AbstractThe anticonvulsant, trimethadione (TMO), was tested for effects on cholinergic responses to iontophoretic application of ACh on identified neurons in Aplysia. TMO (1--10 mM) depressed the amplitudes of depolarizing responses mediated by Na+ and hyperpolarizing responses mediated by Cl- but did not affect hyperpolarizing responses mediated by K+. Such a combination of effects on cholinergic responses distinguishes the action of this anti-absence drug from agents effective against tonic-clonic seizures and from convulsive drugs.

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