• Zhong Nan Da Xue Xue Bao Yi Xue Ban · Dec 2005

    [Correlation between dynamic contrast-enhanced MRI and expression of microvascular density in the glioma].

    • Dan Yin, Xiao-yi Wang, Xue-bin Yan, and Wei-hua Liao.
    • Department of Radiology, Xiangya Hospital, Central South University, Changsha 410008, China). yindan3418@126.com
    • Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2005 Dec 1; 30 (6): 686-9.

    ObjectiveTo explore the correlation between microvascular density (MVD) and dynamic contrast-enhanced MRI in the glioma.MethodsWe examined 35 patients with histologically verified glioma. Gadolinium-enhanced dynamic TurboFLASH imaging was performed preoperatively in all patients followed by conventional MRI. The steepest slope (SSmax) of curve and corresponding Tm1 in "first-pass" phase were obtained by analyzing time-signal curve. All specimens were immunostained with anti-human Factor VIII relative antigen monoclonal antibody postoperatively by streptavidin-peroxidase method to obtain the MVD. The correlation between SSmax, Tm1, and MVD was analyzed.ResultsSSmax was positively correlated with MVD (r = 0.640, P < 0.01). Tml was negatively correlated with MVD (r = -0.671, P < 0.01).ConclusionThe MVD correlates obviously with SSmax and Tml in the glioma. Analyzing the time-signal curve of dynamic contrast-enhanced MRI is helpful to predict the angiogenesis in the glioma.

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