• Drug discovery today · Jun 2002

    Review

    Protein-interaction networks: from experiments to analysis.

    • Vincent Schächter.
    • Hybrigenics, 3-5 Impasse Reille, Paris 75014, France. vschachter@hybrigenics.fr
    • Drug Discov. Today. 2002 Jun 1; 7 (11): S48-54.

    AbstractFunctional proteomics approaches aim to characterize comprehensively the function of gene products, and provide a first-level understanding of cellular mechanisms. Here, we review recent techniques for the construction and prediction of large-scale protein-interaction networks, with a particular emphasis on computational processing steps and comparative assessment of the reliability and completeness of the various approaches. We also discuss the use of protein-interaction network information in functional annotation and in the generation of higher-level biological hypotheses on pathways.

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