• Alice Y Ho, Ase Ballangrud, Guang Li, Gaorav P Gupta, Beryl McCormick, Richard Gewanter, Daphna Gelblum, Melissa Zinovoy, Boris Mueller, Borys Mychalczak, Pinaki Dutta, Karen Borofsky, Preeti Parhar, Marsha Reyngold, Lior Z Braunstein, Mohit Chawla, Kate Krause, Natasha Freeman, Chun Ting Siu, Zachary Cost, Brittany B Arnold, Zhigang Zhang, and Simon N Powell.
• Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York. Electronic address: alice.ho@mgh.harvard.edu.
• Int. J. Radiat. Oncol. Biol. Phys. 2019 Apr 1; 103 (5): 1100-1108.

PurposeMultibeam intensity modulated radiation therapy (IMRT) enhances the therapeutic index by increasing the dosimetric coverage of the targeted tumor tissues while minimizing volumes of adjacent organs receiving high doses of RT. The tradeoff is that a greater volume of lung is exposed to low doses of RT, raising concern about the risk of radiation pneumonitis (RP).Methods And MaterialsBetween July 2010 and January 2013, patients with node-positive breast cancer received inverse-planned, multibeam IMRT to the breast or chest wall and regional nodes, including the internal mammary nodes (IMNs). The primary endpoint was feasibility, predefined by dosimetric treatment planning criteria. Secondary endpoints included the incidence of RP grade 3 or greater and changes in pulmonary function measured with the Common Terminology Criteria for Adverse Events version 3.0 scales, pulmonary function tests and community-acquired pneumonia questionnaires, obtained at baseline and 6 months after IMRT. Clinical follow-up was every 6 months for up to 5 years.ResultsMedian follow-up was 53.4 months (range, 0-82 months). Of 113 patients enrolled, 104 completed follow-up procedures. Coverage of the breast or chest wall and IMN was comprehensive (median 48.1 Gy and 48.9 Gy, respectively). The median volume of lung receiving a high dose (V20Gy) and a low dose (V5) was 29% and 100%, respectively. The overall rate of respiratory toxicities was 10.6% (11/104), including 1 grade 3 RP event (0.96%). No differences were found in pulmonary function test or community-acquired pneumonia scores after IMRT. The 5-year rates of locoregional recurrence-free, disease-free, and overall survival were 93.2%, 63.6%, and 80.3%, respectively.ConclusionsMultibeam IMRT in patients with breast cancer receiving regional nodal irradiation was dosimetrically feasible, based on early treatment planning criteria. Despite the large volume of lung receiving low-dose RT, the incidence of grade 3 RP was remarkably low, justifying inverse-planned IMRT as a treatment modality for patients with high-risk breast cancer in whom conventional RT techniques prove inadequate.Copyright © 2018 Elsevier Inc. All rights reserved.

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