• Kazuro Kikkawa, Akinori Iba, Yasuo Kohjimoto, Yasutaka Noda, Tetsuo Sonomura, and Isao Hara.
• Department of Urology, Wakayama Medical University, Wakayama, Japan.
• Int. J. Urol. 2018 Apr 1; 25 (4): 366-371.

ObjectivesTo evaluate age-related quality of life changes in patients with localized prostate cancer treated by high-dose rate brachytherapy combined with external beam radiation therapy.MethodsA total of 172 patients with clinically localized prostate cancer were categorized to age groups <75 years and ≥75 years. Changes in their quality of life were evaluated using the Japanese version of Medical Outcome Study 8-Items Short Form Health Survey, Expanded Prostate Cancer Index Composite and International Index of Erectile Function-5 at baseline, and followed up to 24 months after treatment.ResultsThere were no significant differences in Medical Outcome Study 8-Items Short Form Health Survey scores, and urinary and bowel scores of the Expanded Prostate Cancer Index Composite for older men after treatment. International Index of Erectile Function-5 summary scores were significantly decreased in both groups. Although sexual function and sexual bother scores were decreased in patients aged <75 years, these scores were maintained in patients aged ≥75 years.ConclusionsQuality of life of prostate cancer patients undergoing high-dose rate brachytherapy combined with external beam radiation therapy does not seem to be significantly affected by age.© 2018 The Japanese Urological Association.

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