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Case Reports
Rapidly Progressive Kidney Failure Associated with Perirenal Capsular Lesion Due to IgG4-Related Disease.
- Nobuhide Endo, Hitomi Shimizu, Tomoki Tanaka, Yukiko Nakase, Tomohiro Kawazoe, and Tomoharu Watanabe.
- Department of Nephrology, Japanese Red Cross Nagoya Daiichi Hospital, Japan.
- Intern. Med. 2021 Jun 15; 60 (12): 1893-1897.
AbstractA 71-year-old Japanese man with progressive kidney failure was referred to our hospital. Laboratory tests showed elevated IgG4 levels. Contrast-enhanced computed tomography (CT) revealed soft tissue surrounding the left kidney and right atrophic kidney. A histopathological examination revealed inflammation and fibrosis with rich IgG4-positive cells in the thickened kidney capsule, but not in the kidney parenchyma. Poor enhancement in the left kidney on contrast-enhanced CT and wrinkling of glomerular capillaries in pathological tissues were also observed. These findings indicated IgG4-related perirenal lesions leading to low renal perfusion and kidney failure. The perirenal lesions and kidney failure were improved by corticosteroid therapy.
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