• Biometrics · Sep 2011

    Minimize the use of minimization with unequal allocation.

    • Michael Proschan, Erica Brittain, and Lisa Kammerman.
    • Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, 6700A Rockledge Drive, Room 5140, Bethesda, Maryland 20892-7609, USA. ProschaM@niaid.nih.gov
    • Biometrics. 2011 Sep 1; 67 (3): 1135-41.

    AbstractMinimization as an alternative to randomization is gaining popularity for small clinical trials. In response to critics' questions about the proper analysis of such a trial, proponents have argued that a rerandomization approach, akin to a permutation test with conventional randomization, can be used. However, they add that this computationally intensive approach is not necessary because its results are very similar to those of a t-test or test of proportions unless the sample size is very small. We show that minimization applied with unequal allocation causes problems that challenge this conventional wisdom.© 2011, The International Biometric Society No claim to original US Federal works.

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