• Endocrine pathology · Dec 2012

    Expression of stromal cell-derived factor 1 and CXCR7 in papillary thyroid carcinoma.

    • Zhen Liu, Da-Xin Sun, Xu-Yong Teng, Wei-Xue Xu, Xiang-Peng Meng, and Bao-Sheng Wang.
    • Department of General Surgery, Shengjing Hospital, China Medical University, Shenyang, China. liuz@sj-hospital.org
    • Endocr. Pathol. 2012 Dec 1; 23 (4): 247-53.

    AbstractStromal cell-derived factor 1 (SDF-1) is a chemokine that is expressed in some cancer cells and is involved in tumor cell migration and metastasis. CXCR7, a novel receptor for SDF-1, has been identified recently. Researches demonstrated that interaction between SDF-1 and CXCR7 could play an important role in cancer progression. In this study, we aimed to investigate the expressions of SDF-1 and CXCR7 and the relationship between their expressions and clinicopathological characteristics in papillary thyroid carcinoma (PTC). Expressions of SDF-1 and CXCR7 in 33 cases of thyroid benign lesion tissue and 79 cases of PTC tissue and peritumoral non-malignant tissue were detected by immunohistochemical staining. Expressions of SDF-1 and CXCR7 were negative in peritumoral non-malignant tissues. Respectively, positive expression rates of SDF-1 and CXCR7 were 69.6 and 65.8 % in PTC, 12.1 and 30.3 % in thyroid benign tissue. The expression of SDF-1 and CXCR7 were positively correlated with lymph node metastasis. SDF-1 and CXCR7 expressions were related with the lymph nodes metastasis of PTC.

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