• Journal of autoimmunity · Aug 2021

    Comparative Study

    Comparison of vaccine-induced thrombotic events between ChAdOx1 nCoV-19 and Ad26.COV.2.S vaccines.

    • Jimin Hwang, Se Bee Lee, Seung Won Lee, Min Ho Lee, Ai Koyanagi, Louis Jacob, Kalthoum Tizaoui, Dong Keon Yon, Jae Il Shin, and Lee Smith.
    • Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA.
    • J. Autoimmun. 2021 Aug 1; 122: 102681.

    AbstractCerebral venous thrombosis (CVT) events have been reported after vaccination with adenoviral COVID-19 vector vaccines. This study aimed to compare the clinical presentations and courses of vaccine-induced thrombotic thrombocytopenia (VITT) between the two adenoviral vector vaccines, Ad26.COV.2.S (Janssen/Johnson & Johnson) and ChAdOx1 nCoV-19 (Astra-Zeneca). We found that CVT after Ad26.COV.2.S vaccination presents later with similar symptoms compared to CVT after administration of ChAdOx1 nCoV-19, albeit with more thrombosis and intracerebral hemorrhage, lower D-dimer and aPTT levels but similar mortality. These findings could help guide clinical assessment and management of CVT after COVID-19 vaccination.Copyright © 2021 Elsevier Ltd. All rights reserved.

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