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J Am Osteopath Assoc · Sep 2002
ReviewUse of nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 (COX-2) inhibitors: indications and complications.
- Richard A Pascucci.
- Philadelphia College of Osteopathic Medicine, Office of Graduate Medical Education, PA 19131-1610, USA. richardp@pcom.edu
- J Am Osteopath Assoc. 2002 Sep 1; 102 (9): 487-9.
AbstractNonsteroidal anti-inflammatory drugs (NSAIDs) are among the most widely used medications-both prescription and over the counter-in the United States. Gastrointestinal side effects from NSAIDs are responsible for significant patient morbidity and mortality as well as healthcare cost. With the development of cyclooxygenase-2 (COX-2) specific inhibitors, these serious adverse reactions have been significantly reduced without affecting therapeutic benefit; however, the need for careful monitoring of patients on therapy with traditional NSAIDs and COX-2 inhibitors continues. In this article, recent developments regarding COX-2 inhibitors and potential future uses of this class of drugs are also discussed.
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