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Gan To Kagaku Ryoho · Apr 2007
[Reduction of oxaliplatin-related neurotoxicity by calcium and magnesium infusions].
- Osamu Muto, Hideaki Ando, Takashi Ono, Hiroko Itagaki, Yoshio Kobayashi, Manabu Onuki, Tatsuru Akashi, Yuichi Tanaka, and Takao Hanaoka.
- Division of Surgery, Nakadori General Hospital.
- Gan To Kagaku Ryoho. 2007 Apr 1;34(4):579-81.
PurposeOxaliplatin in combination with infusional 5-fluorouracil/leucovorin (FOLFOX) have emerged as the standard of care in the therapy of advanced-stage colorectal cancer. Sensory neurotoxicity is its dose-limiting toxicity. We decided to use Ca and Mg for prevention of oxaliplatin-related neurotoxicity with reference to the report of Gamelin et al.MethodsThe subjects were 14 patients with metastatic colorectal cancer. Oxaliplatin (85 mg/m(2)) was given intravenously as FOLFOX regimen. All 14 patients received infusions of Ca gluconate and Mg sulfate before and after oxaliplatin.ResultsOnly 1 patient had grade 3 toxicity (nausea and vomiting). Sensory neuropathy occurred in 8 patients (57.1%). There was no neurotoxicity with functional impairment in this study. Sensory neuropathy hardly occurred before 4 cycles.ConclusionsCa/Mg infusions seem to prevent acute oxaliplatin-induced neurotoxic.
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