• Rev Bras Cir Cardiovasc · Jun 2021

    Extracorporeal Membrane Oxygenation in COVID-19 Treatment: a Systematic Literature Review.

    • Tatiana Farias de Oliveira, Carlos Alberto de Oliveira Rocha, Aisla Graciele Galdino Dos Santos, Luiz Carlos Francelino Silva, Saulo Henrique Salgueiro de Aquino, Euclides José Oliveira da Cunha, Rafaela Campos Alcântara, Rodrigo da Rosa Mesquita, Gabriel Monteiro Arnozo, Fernanda Mayara Santos Santana, Etvaldo Rodrigues da Silva, and Carlos Dornels Freire de Souza.
    • Department of Medicine, Universidade Federal de Alagoas, Arapiraca, Alagoas, Brazil.
    • Rev Bras Cir Cardiovasc. 2021 Jun 1; 36 (3): 388-396.

    IntroductionThe present study intends to systematically review the literature on the use of extracorporeal membrane oxygenation (ECMO) in patients with coronavirus disease 2019 (COVID-19).MethodsThe research was carried out according to the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA). Studies were selected from PubMed/MEDLINE and LILACS databases between December 2019 and May 17 2020, using the descriptors "ECMO AND COVID-19", "Extracorporeal Membrane Oxygenation AND COVID-19", "ECLS AND COVID-19", and "Extracorporeal Life Support AND COVID-19". Exclusion criteria were government epidemiological bulletins, comments, literature reviews, and articles without full access to content.ResultsTwo hundred and thirty-three scientific productions were found, however only 18 did not met the exclusion criteria and could be included in this study, amouting to a total of 911 patients - 624 (68.5%) men, 261 (28.6%) women, and 26 (2.8%) without sex information. The mean age of the patients was 53.7 years. ECMO was necessary in 274 (30.1%) people (200 [73%] submitted to veno-venous ECMO, nine [3.3%] to veno-arterial ECMO, and seven [2.5%] moved between these two types or needed a more specific ECMO according to the disease prognosis). Five studies did not specify the type of ECMO used, amounting 57 (20.8%) patients. Five patients (1.8%) were discharged, 77 (28.1%) died, 125 (45.6%) remained hospitalized until publication time of their respective studies, and 67 patients (24.4%) had no outcome information.ConclusionIt is evident that more research, covering larger populations, must be carried out in order to clearly elucidate the role of ECMO in the treatment of COVID-19.

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