• Iván Posso-Osorio, Juan Naranjo-Escobar, Diana Marcela Loaiza, Marcela Polo, Alex Echeverri, and Gabriel J Tobón.
• GIRAT (Grupo de Investigacion en Reumatologia, Autoinmunidad y Medicina Traslacional) Fundacion Valle del Lili and Universidad Icesi, Cali, Colombia.
• Curr Rheumatol Rev. 2019 Jan 1; 15 (3): 254-258.

BackgroundSjögren's syndrome is an autoimmune disease characterised by exocrinopathy mainly involving the salivary and lacrimal glands. In addition, it is a multisystemic condition (i.e., affecting multiple organs and systems). Neurological involvement has been reported in ~20% of cases, with peripheral manifestations being the most frequent.MethodsWe analysed four cases in which neurological manifestations were the first symptoms of Sjögren's syndrome.ResultsIn all four cases, neurological symptoms preceded sicca symptoms. In addition, immunosuppressive treatment with steroids and, in some cases, cyclophosphamide showed improvement.ConclusionNeurological involvement in Sjögren's syndrome is common and often occurs as the first clinical manifestation. Since evidence is limited, more studies are required in order to determine appropriate diagnostic methods and treatments for each manifestation of Sjögren's syndrome.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

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