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- Pollen K F Yeung.
- Pharmacokinetics & Metabolism Laboratory, College of Pharmacy, Dalhousie University, Halifax, NS B3H-3J5, Canada. pollen.yeung@dal.ca
- Curr Opin Mol Ther. 2003 Jun 1; 5 (3): 315-20.
AbstractGEM-231 (HYBO-165) is an 18mer hybrid oligonucleotide under development by Hybridon for the potential treatment of cancer. Phase I/II dose-escalation trials of GEM-231 in combination with paclitaxel and docetaxel were ongoing in March 2002. At this time, a phase I/II trial of GEM-231 in combination with irinotecan (CPT-11) was initiated in patients with solid tumors. As of February 2003, Hybridon planned to initiate phase II trials in 2003.
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