• J. Cyst. Fibros. · Jan 2015

    Comparative Study

    Comparing Mycobacterium massiliense and Mycobacterium abscessus lung infections in cystic fibrosis patients.

    • Anne-Laure Roux, Emilie Catherinot, Nathalie Soismier, Beate Heym, Gil Bellis, Lydie Lemonnier, Raphaël Chiron, Brigitte Fauroux, Muriel Le Bourgeois, Anne Munck, Isabelle Pin, Isabelle Sermet, Cristina Gutierrez, Nicolas Véziris, Vincent Jarlier, Emmanuelle Cambau, Jean-Louis Herrmann, Didier Guillemot, Jean-Louis Gaillard, and OMA group.
    • EA3647, UFR des Sciences de la Santé Simone Veil, Université de Versailles Saint Quentin en Yvelines (UVSQ), Guyancourt, France; Laboratoire de Microbiologie, Hôpital Raymond Poincaré, Assistance Publique Hôpitaux de Paris (AP-HP), Garches, France. Electronic address: anne-laure.roux@rpc.aphp.fr.
    • J. Cyst. Fibros. 2015 Jan 1; 14 (1): 63-9.

    BackgroundMycobacterium massiliense is closely related to Mycobacterium abscessus and is also a frequent cause of mycobacterial lung disease in patients with cystic fibrosis (CF). There has been no previous investigation of possible differences between M. massiliense and M. abscessus infections in the setting of CF.MethodsWe studied a prospective cohort of 16 M. massiliense and 27 M. abscessus lung infection cases with CF, with a mean follow-up of 6 years.ResultsM. massiliense cases were younger than M. abscessus cases (mean age: 12.8 vs 17.1 years; p=0.02) at the time of the first mycobacterial isolation and also had lower body mass index values (mean: 16.4 vs 19.3 kg/m(2), p=0.002). All M. massiliense cases, except one, had negative BMI Z-score values at the time of the first mycobacterial isolation (11/12 vs 16/23 M. abscessus cases, p=0.04). Clarithromycin-based combination therapies led to mycobacterial eradication in 100% of M. massiliense cases but only in 27% of M. abscessus cases (p=0.009).ConclusionOur data show a particular link between M. massiliense and malnutrition specifically in CF patients. Unlike M. abscessus, the bacteriological response of M. massiliense to combination antibiotic therapies containing clarithromycin was excellent. Distinguishing between M. massiliense and M. abscessus has major clinical implications for CF patients.Copyright © 2014 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.

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