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  • Thorac Cardiovasc Surg · Jun 2018

    Review

    The Value of Circulating Biomarkers in Bicuspid Aortic Valve-Associated Aortopathy.

    • Shiho Naito, Mathias Hillebrand, Alexander Martin Justus Bernhardt, Annika Jagodzinski, Lenard Conradi, Christian Detter, Karsten Sydow, Hermann Reichenspurner, KodolitschYskert vonYVDepartment of Cardiology, University Heart Center Hamburg, Hamburg, Germany., and Evaldas Girdauskas.
    • Department of Cardiac Surgery, Central Hospital Bad Berka, Bad Berka, Germany.
    • Thorac Cardiovasc Surg. 2018 Jun 1; 66 (4): 278-286.

    AbstractTraditional risk stratification model of bicuspid aortic valve (BAV) aortopathy is based on measurement of maximal cross-sectional aortic diameter, definition of proximal aortic shape, and aortic stiffness/elasticity parameters. However, conventional imaging-based criteria are unable to provide reliable information regarding the risk stratification in BAV aortopathy, especially considering the heterogeneous nature of BAV disease. Given those limitations of conventional imaging, there is a growing clinical interest to use circulating biomarkers in the screening process for thoracic aortic aneurysms as well as in the risk-assessment algorithms. We aimed to systematically review currently available biomarkers, which may be of value to predict the natural evolution of aortopathy in individuals with BAV.Georg Thieme Verlag KG Stuttgart · New York.

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