• Thomas M Gill, Jack M Guralnik, Marco Pahor, Timothy Church, Roger A Fielding, Abby C King, Anthony P Marsh, Anne B Newman, Christine A Pellegrini, Shyh-Huei Chen, Heather G Allore, Michael E Miller, and LIFE Study Investigators.
• From Yale School of Medicine, New Haven, Connecticut; University of Maryland School of Medicine, Baltimore, Maryland; University of Florida, Gainesville, Florida; Pennington Biomedical Research Center, Baton Rouge, Louisiana; Tufts University, Boston, Massachusetts; Stanford School of Medicine, Stanford, California; Wake Forest University and Wake Forest School of Medicine, Winston-Salem, North Carolina; University of Pittsburgh, Pittsburgh, Pennsylvania; and Northwestern University Feinberg School of Medicine, Chicago, Illinois.
• Ann. Intern. Med. 2016 Dec 20; 165 (12): 833-840.

BackgroundThe total time a patient is disabled likely has a greater influence on his or her quality of life than the initial occurrence of disability alone.ObjectiveTo compare the effect of a long-term, structured physical activity program with that of a health education intervention on the proportion of patient assessments indicating major mobility disability (MMD) (that is, MMD burden) and on the risk for transitions into and out of MMD.DesignSingle-blinded, parallel-group, randomized trial. (ClinicalTrials.gov: NCT01072500).Setting8 U.S. centers between February 2010 and December 2013.Participants1635 sedentary persons, aged 70 to 89 years, who had functional limitations but could walk 400 m.InterventionPhysical activity (n = 818) and health education (n = 817).MeasurementsMMD, defined as the inability to walk 400 m, was assessed every 6 months for up to 3.5 years.ResultsDuring a median follow-up of 2.7 years, the proportion of assessments showing MMD was substantially lower in the physical activity (0.13 [95% CI, 0.11 to 0.15]) than the health education (0.17 [CI, 0.15 to 0.19]) group, yielding a risk ratio of 0.75 (CI, 0.64 to 0.89). In a multistate model, the hazard ratios for comparisons of physical activity with health education were 0.87 (CI, 0.73 to 1.03) for the transition from no MMD to MMD; 0.52 (CI, 0.10 to 2.67) for no MMD to death; 1.33 (CI, 0.99 to 1.77) for MMD to no MMD; and 1.92 (CI, 1.15 to 3.20) for MMD to death.LimitationThe intention-to-treat principle was maintained for MMD burden and first transition out of no MMD, but not for subsequent transitions.ConclusionA structured physical activity program reduced the MMD burden for an extended period, in part through enhanced recovery after the onset of disability and diminished risk for subsequent disability episodes.Primary Funding SourceNational Institute on Aging, National Institutes of Health.

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