• Marcos Fragiel, Òscar Miró, Pere Llorens, Sònia Jiménez, Pascual Piñera, Guillermo Burillo, Alfonso Martín, Francisco J Martín-Sánchez, Eric J García-Lamberechts, Javier Jacob, Aitor Alquézar-Arbé, Ricardo Juárez, Blas Jiménez, Rigoberto Del Rio, Miriam Mateo Roca, Arturo H García, Nieves López Laguna, María P Lopez Diez, Jorge Pedraza García, Amparo Fernández de Simón Almela, Juan J Lopez Diaz, Patricia Eiroa Hernández, Noemí Ruiz de Lobera, Jesús Porta-Etessam, Cristina Fernández Pérez, Elpidio Calvo, Juan González Del Castillo, and SIESTA (Spanish Investigators in Emergency Situations Team) network.
• Emergency Department, San Carlos Clinical Hospital, Instituto de Investigación Sanitaria San Carlos (San Carlos Health Research Institute), Complutense University, Madrid, Spain.
• Ann. Neurol. 2021 Mar 1; 89 (3): 598-603.

AbstractWe diagnosed 11 Guillain-Barré syndrome (GBS) cases among 71,904 COVID patients attended at 61 Spanish emergency departments (EDs) during the 2-month pandemic peak. The relative frequency of GBS among ED patients was higher in COVID (0.15‰) than non-COVID (0.02‰) patients (odds ratio [OR] = 6.30, 95% confidence interval [CI] = 3.18-12.5), as was the standardized incidence (9.44 and 0.69 cases/100,000 inhabitant-years, respectively, OR = 13.5, 95% CI = 9.87-18.4). Regarding clinical characteristics, olfactory-gustatory disorders were more frequent in COVID-GBS than non-COVID-GBS (OR = 27.59, 95% CI = 1.296-587) and COVID-non-GBS (OR = 7.875, 95% CI = 1.587-39.09) patients. Although COVID-GBS patients were more frequently admitted to intensive care, mortality was not increased versus control groups. Our results suggest SARS-CoV-2 could be another viral infection causing GBS. ANN NEUROL 2021;89:598-603.© 2020 American Neurological Association.

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