• Bioorg. Med. Chem. Lett. · Mar 2014

    Identification of a methoxynaphthalene scaffold as a core replacement in quinolizidinone amide M(1) positive allosteric modulators.

    • Scott D Kuduk, Christina N Di Marco, Jonathan R Saffold, William J Ray, Lei Ma, Marion Wittmann, Kenneth A Koeplinger, Charles D Thompson, George D Hartman, Mark T Bilodeau, and Douglas C Beshore.
    • Department of Medicinal Chemistry, Sumneytown Pike, PO Box 4, West Point, PA 19486, USA. Electronic address: scott_d_kuduk@merck.com.
    • Bioorg. Med. Chem. Lett. 2014 Mar 1; 24 (5): 1417-20.

    AbstractA series of methoxynaphthalene amides were prepared and evaluated as alternatives to quinolizidinone amide M1 positive allosteric modulators. A methoxy group was optimal for M1 activity and addressed key P-gp issues present in the aforementioned quinolizidinone amide series. Copyright © 2014 Elsevier Ltd. All rights reserved.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…