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- Jonas Dyhrfjeld-Johnsen, Sophie Gaboyard-Niay, Audrey Broussy, Aurélie Saleur, Aurore Brugeaud, and Christian Chabbert.
- Sensorion, Montpellier, France.
- J Vestib Res. 2013 Jan 1; 23 (3): 177-86.
AbstractVestibular neuritis is a neuroinflammatory, peripheral vestibular pathology leading to chronic deficits and long-term disability. While current corticosteroid-based therapy does not appear to positively influence the long term outcome for the patient, a recent clinical pilot study suggested a functional vestibuloprotective effect of the anti-emetic ondansetron in the treatment of vestibular neuritis. We here demonstrate that systemic post-insult administration of ondansetron in a novel rat model of severe excitotoxic vestibular insult reproduces the clinically demonstrated functional benefits. This ondansetron-conferred reduction of functional deficits stems from the protection of synapses between sensory hair cells and primary neurons from excitotoxically induced lesion.
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