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J. Thromb. Haemost. · Nov 2017
Randomized Controlled TrialReversal of apixaban anticoagulation by four-factor prothrombin complex concentrates in healthy subjects: a randomized three-period crossover study.
- Y Song, Z Wang, I Perlstein, J Wang, F LaCreta, R J A Frost, and C Frost.
- Bristol-Myers Squibb, Princeton, NJ, USA.
- J. Thromb. Haemost. 2017 Nov 1; 15 (11): 2125-2137.
AbstractEssentials Prothrombin complex concentrates (PCCs) may reverse the effect of factor Xa (FXa) inhibitors. We conducted an open-label, randomized, placebo-controlled, three-period crossover study in 15 subjects. Both PCCs rapidly reversed apixaban-mediated decreases in mean endogenous thrombin potential. Four-factor PCC administration had no effect on apixaban pharmacokinetics or anti-FXa activity.© 2017 International Society on Thrombosis and Haemostasis.
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